Tired men are everyday story of a young couple where man suddenly get heart problems. He must deal with his new situation, like working, as a young father and husband, and struggling to accept that lifestyle and stress has he sat back with a risk disease at a young age. The film is based on Ulla-Britt Lilleaas' research on men's terms of health, work and family.

Thomas breaks down after his girlfriend leaves him, and starts going to therapy groups.